Corneal alteration and pathogenesis in diabetes mellitus

• 作者: Bai-Hua Chen Han Zhao Yan He Yue-Rong Ren
• 来源期刊: 国际眼科杂志:英文版
• 学科: 医学
• 关键词: diabetes mellitus DIABETIC KERATOPATHY DIABETIC NEUROPATHY in vivo CONFOCAL microscopy advanced glycation end products
• 年，卷（期）: 2019,（12）
• 页码范围: 1939-1950
• 页数: 12页
• 分类号: R58

摘要

The incidence of diabetes mellitus(DM) and its complications have increased considerably worldwide. Diabetic keratopathy is the major complication of the cornea characterized by delayed corneal wound healing, decreasing corneal epithelial sensitivity, and recurrent corneal ulcers. There is accumulating evidence that diabetic keratopathy is correlated with the hyperglycemic state. Different corneal components may produce different alterations under hyperglycemia. In addition, diabetic nerve alteration may become a novel biomarker of earlystage DM. Abnormalities of the corneal nerve plexus have been associated with diabetic inflammatory states. There is rapidly growing evidence based on investigations of diabetic corneal nerves through in vivo confocal microscopy. Understanding the molecular pathogenesis caused by hyperglycemia may assist in the identification of novel biomarkers, as well as therapeutic targets for early treatment. This review mainly summarizes recent findings on corneal alteration and pathogenesis in DM.