Based on natural protein materials,a series of lenses with different heights and focal lengths were assembled on glass substrates by femtosecond laser non-contact,masking,and cold processing.This lens array itself possesses unique and characteristic optical performance in three-dimensional parallel imaging and bending imaging.What is more profound is that by using equilibrium swelling of protein-hydrogel,once the lens array was placed in a liquid environment,with the change of ion concentration (e.g.,pH),the refractive index and curvature of the protein-hydrogel would change,which leads to the flex of the focal plane of the lens,finally realizing the dynamical tunability of a protein microlens.These smart stress devices may have great potential in optical biosensing and microfluidic chip integration fields.