Biogeographical informativeness of Y-STR haplotypes
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摘要:
Research on biogeographical ancestry (BGA) is becoming of growing interest in forensic genetics and in the biomedical literature [1].Thus,for instance,the need to predict ethnicity of an unknown suspect based on DNA profiles found at the crime scene is of maximum interest in criminalistics [2],and several autosomal SNP panels have been designed and tested for BGA investigations [3,4].Most of these panels aim at discriminating three main continental groups (sub-Saharan Africans,Europeans,and Asians) by way of testing a number of ancestry informative markers (AIMs) that run from a few dozens to a few hundred [5] (see more background in Supplementary data online).