Degradation of CTLA-4 balances toxicity and efficacy

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2019,（19）
• 页码范围: 1388-1389
• 页数: 2页
• 语种: 英文

摘要

The notorious side effects of anti-CTLA-4 limit its use in the clinic,but what causes the severe side effects remains largely unclear.Zhang et al.[1] elucidated antibody-induced CTLA-4 lysosomal degradation as a new mechanism accounting for the severe immunotherapy-related adverse effects and limited efficacy of anti-CTLA-4 therapy.