Damps' role in inflammatory bowel disease: a paradoxical player of mtDNA-STING signaling pathway in gut homeostasis

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2019,（19）
• 页码范围: 1396-1398
• 页数: 3页
• 语种: 英文

摘要

The inflammatory bowel disease (IBD),including Crohn's disease (CD) and ulcerative colitis,are chronic,relapsing immune mediated disorders of the gastrointestinal homeostasis and intestinal inflammation [1].Failure to resolve mucosal inflammation and maintain gut barrier are notable shared clinical challenges in IBD management.Increasing evidence indicated that "damage associated molecular patterns" (DAMPs) as "alarmins" or "danger stimuli" can initiate and maintain mucosal inflammation in IBD,in particular when they activate immune cells within the gut lamia propria.