Effect of individualized therapy for AIDS patients with cytomegalovirus retinitis in intravitreal ganciclovir injections

• 作者: Chao Chen Chun-Gang Guo Hong-Wei Dong Kui-Fang Du Lian-Yong Xie Wen-Bin Wei Wen-Jun Kong
• 来源期刊: 国际眼科杂志:英文版
• 学科: 医学
• 关键词: CYTOMEGALOVIRUS RETINITIS acquired immune deficiency syndrome GANCICLOVIR INTRAVITREAL injection MONOTHERAPY
• 年，卷（期）: gjykzzywb_2019,（8）
• 页码范围: 1351-1355
• 页数: 5页
• 分类号: R512.91

摘要

The effect of intravitreal ganciclovir injection combined with intravenous infusion on acquired immune deficiency syndrome(AIDS) patients with cytomegalovirus retinitis(CMVR) was investigated. A total of 32 eyes in 23 AIDS patients diagnosed as CMVR from 2017 to 2018 were included in the retrospective study. All patients underwent induction therapy by using intravenous drip of the anticytomegalovirus(CMV) agent ganciclovir(5 mg/kg q12 h) combined with intravitreal ganciclovir injection(3 mg/time, 2 times/wk). The visual acuity, fundus photographs, lesion location, and number of intravitreal injections were observed preoperatively and postoperatively. Totally 14 eyes were cured during induction therapy. The number of injections [4.13(2 to 6)] in CMVR patients with peripherally fundus lesions were significantly lower than those with central lesions (4.89(2 to 6))The individualized therapy of intravitreal ganciclovir injections for AIDS patients with CMVR can effectively reduce the numbers of intravitreal injections.