Myopia genetics in genome-wide association and postgenome-wide association study era

• 作者: Chang-Jun Lan Qing-Qing Tan Xuan Liao
• 来源期刊: 国际眼科杂志:英文版
• 学科: 医学
• 关键词: MYOPIA GENETIC variation GENOME-WIDE association studies OMICS
• 年，卷（期）: gjykzzywb_2019,（9）
• 页码范围: 1487-1492
• 页数: 6页
• 分类号: R778.11

摘要

Genome-wide association studies(GWAS) of myopia and refractive error have generated exciting results and identified novel risk-associated loci. However, the interpretation of the findings of GWAS of complex diseases is not straightforward and has remained challenging. This review provides a brief summary of the main focus on the advantages and limitations of GWAS of myopia, with potential strategies that may contribute to further insight into the genetics of myopia in the post-GWAS or omics era.