Network pharmacology-based screening of the active ingredients and potential targets of the Patrinia villosa for application to Alzheimer’s disease

• 作者: Ming Bai Shaojiang Song Shuhui Dong Xiaoxiao Huang Zhikang Duan
• 来源期刊: 亚洲传统医药
• 学科: 医学
• 关键词: Patrinia villosa J. network PHARMACOLOGY Alzheimer’s disease
• 年，卷（期）: 2020,（1）
• 页码范围: 1-7
• 页数: 7页
• 分类号: R74

摘要

Alzheimer’s disease(AD)is a progressive neurodegenerative disorder associated with global deterioration of intellectual function,including memory,learning,orientation,language,comprehension and judgment.Given the prevalence of AD and the lack of effective long-term therapies,there is a pressing need to discover viable leads that can be developed into clinically approved drugs with disease-modifying effects.The analysis of current reported literatures confirms the importance of Patrinia villosa J.as candidate against AD.Hence,the compound-disease target network based on the methods of network pharmacology prediction was established in this paper.The aim is to explore potential compounds with marked effect on AD in P.villosa.The result showed that the most effective compound in this plant might be threo-(7R,8R)-guaiacyl-glycerol-β-O-4′-dihydroconiferyl ether,and the most potential target might be Maltose-binding periplasmic.