Special topic: Emerging role of transporters in drug interaction and delivery

• 作者: Jin Sun Longfa Kou Zhonggui He
• 来源期刊: 亚洲药物制剂科学(英文)
• 学科: 教育
• 关键词: METABOLISM utilized finding
• 年，卷（期）: 2020,（2）
• 页码范围: 129-130
• 页数: 2页
• 分类号: G62

摘要

To date,over 400 membrane transporters have been identified and characterized in human cells at both the molecular level and functional level.These transporters are classified into two families:ATP-binding cassette(ABC)transporters and solute carrier(SLC)transporters.They are well-recognized determinants of drug disposition and metabolism,even in the development of some diseases.Due to the biological function and tissue-specific expression,transporters play a potent role not only in drug disposition but also in drug-drug/drug-food interaction,and hold great potential to be utilized as targets for drug delivery.In 2019,we published a printed book entitled Drug Transporters(PMPH 2019;ISBN 978-7-117-28219-2)in Chinese.The content of the PMPH 2019 book included the basic transporter information and its role in diseases,drug-drug interaction,and drug delivery.However,the printed PMPH 2019 book was started in 2015.The field is growing so fast that several new emerging areas were uncovered in the book,which motivated us to propose a special issue that focuses on the latest advances of drug transporters in drug interaction and delivery.In this issue,we would like to invite several contributors to discuss the emerging findings regarding transporters and drugs.