Meta-analysis of Laparoscopic cyst decortication versus traditional open cyst decortication for ADPKD in China: evidence based on 362 cases and 399 controls

• 作者: Jian-Dong Gao Jing Gan Sheng-Qiang Yu Xin Guan Yi-Yi Ma
• 来源期刊: TMR理论与假说
• 学科: 医学
• 关键词: LCD OCD ADPKD META-ANALYSIS
• 年，卷（期）: 2020,（1）
• 页码范围: 268-280
• 页数: 13页
• 分类号: R74

摘要

Objectives:To assess the safety,feasibility and clinical benefits of LCD and OCD for the treatment of ADPKD.Methods:Databases articles comparing LCD and OCD in treating PKD were collected through March 2019.After screening for inclusion and data extraction,meta-analysis was performed by the RevMan 5.3 software.Results:A total of 9 studies involving 761 patients were finally included,with 362 cases in LCD group and 399 cases in OCD group.LCD was associated with a shorter operative time(MD=-36.24,95%CI:-44.20~-28.28,P<0.00001)and postoperative hospital stay(MD=-4.04,95%CI:-5.13~-2.95,P<0.00001).Besides,LCD had an earlier time to postoperative ambulation(MD=-14.90,95%CI:-16.33~-13.48,P<0.00001)and earlier time to first flatus(MD=-1.52 days,95%CI:-1.65~-1.40,P<0.00001;MD=-10.76 hours,95%CI:-12.71~-8.81,P<0.00001).In addition,LCD had a lower intraoperative blood loss(MD=-159.81,95%CI:-243.32~-76.31,P=0.0002)and lower analgesic dosage(MD=-56.62,95%CI:-84.16~-29.08,P<0.0001).There showed no statistically significant difference between the two groups in Scr,Bun,systolic and diastolic blood pressure(all P>0.05).Conclusions:Current evidence demonstrated a shorter postoperative hospital stay,lower blood loss,less postoperative pain,and other advantages.LCD may therefore be a feasible and safe surgical approach of ADPKD.