基本信息来源于合作网站,原文需代理用户跳转至来源网站获取       
摘要:
The significant function of Toll-like receptors (TLR) is the detection of microbes by host guard cells that guide to the innate immune responses and to the successive adaptive. The current study patterns of TLR2, TLR3 and TLR9 expressing antigen presenting cells (APCs) in blood of mice after colonization with L. plantarum NC8 strain were assessed. The power of L. plantarum on serum innate cytokine and TLR responses stimulated by recombinant NC8-pSIP409-pgsA-VP6-DCpep, NC8-pSIP409-pgsA-VP7-DCpep and NC8-pSIP409-pgsA were also assessed. We confirmed that L. plantarum NC8 stimulated powerful TLR2 expressing APC responses in blood Recombinant strain stimulated a TLR3 response in spleen, and TLR9 responses were stimulated in blood or in spleen. Recombinant NC8-pSIP409-pgsA-VP6-DCpep, NC8-pSIP409-pgsA-VP7-DCpep on TLR2 and TLR9 expressing APC responses has a preservative outcome, reliable with the DCpep adjuvant outcome. In serum the recombinant NC8-pSIP409-pgsA-VP6-DCpep, NC8-pSIP409-pgsA-VP7-DCpep has increased the IL-4 and IFN-γ responses, except that on the TLR3 and TLR9 expressing CD14 APC responses it had an oppressive consequence in spleen and the IFN-α response in serum-stimulated by PRV. Our results give details that following PRV infection after immunization with NC8-pSIP409-pgsA-VP6-DCpep, NC8-pSIP409-pgsA-VP7-DCpep, the systemic TLR2, TLR3, and TLR9 expressing cDC and macrophage/monocyte responses.
推荐文章
基因I型草鱼呼肠孤病毒VP7蛋白合成肽抗体的制备及应用
草鱼呼肠孤病毒(GCRV)
基因I型
VP7蛋白
原核表达
合成肽抗体
华东地区猪A群轮状病毒的VP7和VP4基因序列分析
华东地区
VP7
VP4
序列分析
猪A群轮状病毒
抗原表位
结构蛋白VP4、VP6和VP7对牛轮状病毒的致病作用
轮状病毒
结构蛋白VP4
结构蛋白VP6
结构蛋白VP7
猪轮状病毒中国分离株JL94 VP7基因的克隆与序列分析
猪轮状病毒
VP7基因
克隆
序列分析
内容分析
关键词云
关键词热度
相关文献总数  
(/次)
(/年)
文献信息
篇名 Innate Cytokine Responses and Toll-Like Receptor Induced by Recombinant Porcine Rotavirus VP6 and VP7 Proteins Expressing in <i>Lactobacillus plantarum</i>NC8 Strain Colonization in Mice
来源期刊 疫苗(英文) 学科 医学
关键词 TOLL-LIKE Receptors RECOMBINANT Porcine ROTAVIRUS Lactobacillus plantaram MICE
年,卷(期) 2020,(1) 所属期刊栏目
研究方向 页码范围 17-31
页数 15页 分类号 R73
字数 语种
DOI
五维指标
传播情况
(/次)
(/年)
引文网络
引文网络
二级参考文献  (0)
共引文献  (0)
参考文献  (0)
节点文献
引证文献  (0)
同被引文献  (0)
二级引证文献  (0)
2020(0)
  • 参考文献(0)
  • 二级参考文献(0)
  • 引证文献(0)
  • 二级引证文献(0)
研究主题发展历程
节点文献
TOLL-LIKE
Receptors
RECOMBINANT
Porcine
ROTAVIRUS
Lactobacillus
plantaram
MICE
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
疫苗(英文)
季刊
2160-5815
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
48
总下载数(次)
0
论文1v1指导