A Network Pharmacology Approach to Investigate the Mechanisms of Huangqin Decoction in the Treatment of Irinotecan-Induced Gastrointestinal Toxicity

• 作者: Qing Xu Yu Wang Zheng-Quan Feng
• 来源期刊: 亚洲毒理学研究
• 学科: 医学
• 关键词: Network PHARMACOLOGY Huangqin DECOCTION IRINOTECAN GASTROINTESTINAL toxicity PATHOGENESIS
• 年，卷（期）: 2020,（1）
• 页码范围: 8-21
• 页数: 14页
• 分类号: R28

摘要

Objective:To find out the potential mechanisms of Huangqin decoction in the treatment of irinotecan-induced gastrointestinal toxicity.Methods:A network pharmacology approach was used to analyze the active compounds,drug targets and interacting pathways of Huangqin decoction in treating irinotecan-induced gastrointestinal toxicity.The compounds and predicted targets of Huangqin decoction were screened from TCMSP,and the disease targets were obtained from GeneCards.The therapeutic mechanisms of action of the Huangqin decoction were analyzed by gene ontology(GO)enrichment,Kyoto encyclopedia of genes and genomes pathway(KEGG)enrichment analyses.Results:The results show that 161compounds and 143 targets were obtained in this work.These targets were further mapped to 216 GO biological process terms and 30 remarkably pathways.Active compounds,targets,and pathways were used to construct a compound-target network.These results indicated that Huangqin decoction may treat the irinotecan-induced gastrointestinal toxicity mainly from intervening in the mucosal inflammation,cell apoptosis process,and cell proliferation.Conclusion:This study confirmed that the active components of Huangqin decoction play an important role in the treatment of irinotecan-related gastrointestinal toxicity through multi-target and multi-pathway,which provides a new way for the pathogenesis of irinotecan-related gastrointestinal toxicity.It facilitates the modernization of herbal medicine for complex diseases in the future.