Lessons from“real life experience”of rifaximin use in the management of recurrent hepatic encephalopathy

• 作者: Charlène Cool Christophe Bureau Fiona Chautant Hortensia Lison Jean-Fran?ois Cadranel Jean-Marie Peron Maeva Guillaume Marie-Angèle Robic Véronique Duhalde
• 来源期刊: 世界肝病学杂志:英文版(电子版)
• 学科: 医学
• 关键词: RIFAXIMIN Hepatic ENCEPHALOPATHY CIRRHOSIS Liver disease HOSPITALIZATION
• 年，卷（期）: 2020,（1）
• 页码范围: 10-20
• 页数: 11页
• 分类号: R73

摘要

BACKGROUND Hepatic encephalopathy(HE)is a major complication of cirrhosis with independent prognostic significance.The current management of HE is mainly based on lactulose.Rifaximin has been shown to decrease the risk of HE recurrence in patients with episodic forms.HE can also be persistent.However,there is no drug support recommendation for rifaximin use in this setting.AIM To assess the effectiveness of rifaximin in the management of recurrent episodes of HE and recurrent acute exacerbations on persistent HE,in“real life conditions”.METHODS In this retrospective study,using a within-subjects design,we collected data of patients treated with rifaximin for HE in two liver diseases centers,during the six-month period before and during the six-month period after the initiation of rifaximin.The primary effectiveness endpoint was the total number of HE events involving hospitalization.RESULTS Rifaximin was introduced for prevention of recurrent HE episodes in 29 out of 62 patients with normal mental status between episodes and for prevention of recurrent acute exacerbations on persistent HE in 33 out of 62 patients.In the“prevention of recurrent HE episodes”group,fewer HE events(0.79 vs 1.78;P=0.013)were reported during the period of time when rifaximin was used.In the“prevention of recurrent acute exacerbations on persistent HE”group,there was no significant difference in the number of HE-events(1.48 vs 1.77;P=0.582).CONCLUSION In this real-life experience,the effectiveness of rifaximin was confirmed in the prevention of HE episodes recurrence but was not proved in the prevention of acute exacerbations recurrence on persistent HE.