Interaction between LCSCs and lung cancer microenvironment and TCM intervention

• 作者: Ming-Xin Wu Rui-Yu Mou Shan-Qi Guo Xiao-Di Liu Xiao-Jiang Li
• 来源期刊: 肿瘤微环境研究
• 学科: 医学
• 关键词: LUNG CANCER LUNG CANCER stem cells LUNG CANCER MICROENVIRONMENT
• 年，卷（期）: zlwhjyj_2020,（1）
• 页码范围: 16-22
• 页数: 7页
• 分类号: R73

摘要

Lung cancer has become a leading cause of cancer-related death because of its high morbidity and mortality.Although some progress has been made in the diagnosis,surgery,chemoradiotherapy,and other aspects of lung cancer in the last decade,actually there is no substantial breakthrough for the 5-year survival rate of patients has no significant improvement and is still below 15%.Plenty of evidence suggests that malignant tumors including lung cancer have a unique subgroup of cells featured with self-renewal and multidirectional differentiation potential.Cancer stem cells(CSCs)are the root of tumor growth and metastasis,and the characteristic changes of malignant phenotype(such as recurrence,invasion and metastasis,and drug resistance)are closely linked with CSCs.This paper explored the possible correlated mechanism of the complex interaction between lung cancer stem cells(LCSCs)and lung cancer microenvironment,to provide ideas for the R&D of relevant treatment technologies,the promotion of the progress in traditional medical technology,and the breakthrough of the bottleneck of long-term effect of lung cancer.