Malignant Peripheral Nerve Sheath Tumor of the Thigh Invading the Superficial Femoral Artery, with Necrotic Lung Metastases as Presenting Symptoms

• 作者: François Buche Geoffrey Colin Patrick Mailleux
• 来源期刊: 肺癌(英文)
• 学科: 医学
• 关键词: Necrotic Metastasis Malignant Peripheral Nerve Sheath Tumor NF1 Lung Adenocarcinoma ¹⁸F-FDG PET/CT Unknown Primary Tumor
• 年，卷（期）: 2020,（2）
• 页码范围: 24-29
• 页数: 6页
• 分类号: R73

摘要

A NF1 (neurofibromatosis 1) patient developed multiple necrotic lung metastases</span><span style="font-family:Verdana;"> from a sciatic malignant peripheral nerve sheath tumor (MPNST) invading the superficial femoral artery. The first diagnosis was metastases of a non-small-cell adenocarcinoma because the right calf MPNST was not clinical</span><span style="font-family:Verdana;">ly noticeable ant that the chest/abdomen PET/CT did not include the region of the legs. When the MPNST was diagnosed, new histological analysis on the </span><span style="font-family:Verdana;">metastases changed the diagnosis to that of epithelioid undifferentiated sarcoma.</span><span style="font-family:Verdana;"> The article deals with the sometimes-delayed diagnosis in those NF1 patients </span><span style="font-family:Verdana;">with large palpable masses and chronic pain pre-existing the malignant transformat</span><span style="font-family:Verdana;">ion, and discusses the difficulty of the biopsy of necrotic metastases.