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The generation of cellular energy in the form of ATP occurs mainly in mitochondria by oxidative phosphorylation.Cytochrome c oxidase(CytOx),the oxygen accepting and rate-limiting step of the respiratory chain,regulates the supply of variable ATP demands in cells by“allosteric ATP-inhibition of CytOx.”This mechanism is based on inhibition of oxygen uptake of CytOx at high ATP/ADP ratios and low ferrocytochrome c concentrations in the mitochondrial matrix via cooperative interaction of the two substrate binding sites in dimeric CytOx.The mechanism keeps mitochondrial membrane potentialΔΨm and reactive oxygen species(ROS)formation at low healthy values.Stress signals increase cytosolic calcium leading to Ca^2+-dependent dephosphorylation of CytOx subunit I at the cytosolic side accompanied by switching off the allosteric ATPinhibition and monomerization of CytOx.This is followed by increase ofΔΨm and formation of ROS.A hypothesis is presented suggesting a dynamic change of binding of NDUFA4,originally identified as a subunit of complex I,between monomeric CytOx(active state with highΔΨm,high ROS and low efficiency)and complex I(resting state with lowΔΨm,low ROS and high efficiency).
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篇名 Regulation of cytochrome c oxidase contributes to health and optimal life
来源期刊 世界生物化学杂志:英文版(电子版) 学科 化学
关键词 Cytochrome c oxidase Regulation of respiration Allosteric ATP-inhibition NDUFA4 Reversible phosphorylation Efficiency of ATP synthesis Dimerization of cytochrome c oxidase
年,卷(期) 2020,(2) 所属期刊栏目
研究方向 页码范围 52-61
页数 10页 分类号 O62
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Cytochrome
c
oxidase
Regulation
of
respiration
Allosteric
ATP-inhibition
NDUFA4
Reversible
phosphorylation
Efficiency
of
ATP
synthesis
Dimerization
of
cytochrome
c
oxidase
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界生物化学杂志:英文版(电子版)
季刊
1949-8454
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
391
总下载数(次)
0
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