Mechanism of aseptic inflammation upon the inner ear injury

• 作者: Ren Dongdong Wang Yanmei
• 来源期刊: 生物组学研究杂志（英文）
• 关键词: age-related hearing loss immune response inflammatory response macrophages sudden sensorineural hearing loss
• 年，卷（期）: 2020,（2）
• 所属期刊栏目: Review Article
• 页码范围: 72-77
• 页数: 6页
• 语种: 中文
• DOI: 10.1097/JBR.0000000000000041

摘要

Many factors can cause inner ear injury, such as noise exposure, chemicals, viral infection, and radiation. The main pathological manifestations of inner ear injury are local hypoxia-ischemia, micro-trauma, and an increased level of reactive oxygen species and inflammatory mediators. The contribution of the inflammatory response to the mediation of cochlear and vestibular pathologies has received increasing attention in recent years. Aseptic inflammation can devastate audition and balance, which can lead to many typical clinical inner ear diseases. In this review, we will discuss the most pertinent and recent research on inflammatory mechanisms in inner ear injury. We will also discuss the pathophysiology of some common and significant ear diseases, such as sudden sensorineural hearing loss, age-related hearing loss, noise-induced hearing loss, and Meniere’s disease.