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<strong>Background:</strong> In Nigeria Pentavalent vaccine had replaced Diphtheria-Pertussis- Tetanus [DPT] vaccine in the prevention of pertussis since 2012. <strong>Aims and Objectives:</strong> The aim of this study was to compare the anti-pertussis immunoglobin G (IgG) response of children who received DPT with those who received the pentavalent vaccine. <strong>Subjects and Methods:</strong> This study was carried out in Akpabuyo LGA of Cross River State from April to June 2016. It was a cross-sectional survey of anti-pertussis IgG levels in children aged 6 months to 5 years who received DPT and those who received pentavalent vaccine. IgG antibody levels were determined using enzyme-linked immunosorbent assay. The protective level was set at >11 DU according to manufacturer’s cut off point. <strong>Results:</strong> Seventy eight out of 230 children [33.9%] who had received DPT had protective levels of anti-pertussis IgG compared to 74 out of 192 children [38.5%] who had received pentavalent vaccine. The difference was not statistically significant [<em>p</em> = 0.61]. The median IgG antibody level in those who received DPT was 8.0 DU (interquartile range (IQR) 4.0 - 13.0) compared with 9.0 DU (IQR) 4.0 - 15.0 in those who received pentavalent vaccine [<em>p</em> = 0.18]. No single factor investigated predicted the development of protective levels of antibody in the multivariate analysis. <strong>Conclusion/Recommendation:</strong> There was no difference in the antipertussis antibody response between DPT and pentavalent vaccines recipients. Further study is needed to elucidate factors that could be responsible for low anti-pertussis antibody response in this population.
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篇名 Comparative Pertussis Antibody Response of Nigerian Children to Diphtheria, Pertussis, Tetanus (DPT) and Pentavalent Vaccines
来源期刊 疫苗(英文) 学科 医学
关键词 Anti-Pertussis Immunoglobulin G Diphtheria-Pertussis-Tetanus Pentavalent Vaccine COMPARATIVE
年,卷(期) 2020,(3) 所属期刊栏目
研究方向 页码范围 43-53
页数 11页 分类号 R18
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Anti-Pertussis
Immunoglobulin
G
Diphtheria-Pertussis-Tetanus
Pentavalent
Vaccine
COMPARATIVE
研究起点
研究来源
研究分支
研究去脉
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相关学者/机构
期刊影响力
疫苗(英文)
季刊
2160-5815
武汉市江夏区汤逊湖北路38号光谷总部空间
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48
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0
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