Serum Irisin:Pathogenesis and Clinical Research in Cardiovascular Diseases

• 作者: Kader Eliz Uze Lutfu Askin Okan Tanriverdi Serdar Turkmen
• 来源期刊: Cardiovascular Innovations and Applications
• 学科: 医学
• 关键词: INSULIN resistance irisin CARDIOVASCULAR DISEASES body mass index
• 年，卷（期）: 2020,（1）
• 页码范围: 195-200
• 页数: 6页
• 分类号: R73

摘要

Recently,muscular function/dysfunction has gained importance in the maintenance of metabolic homeostasis in cardiovascular diseases.Skeletal muscle plays a vital role in coordinating the activity and metabolism of endocrine organs by secreting many myokines,especially irisin.Irisin is a polypeptide hormone consisting of 112 amino acids secreted into the blood from muscle and adipose tissues.Serum irisin levels are associated with cardiometabolic risk factors such as obesity and insulin resistance as defi ned by homeostatic model assessment.Irisin reduces endothelial damage by inhibiting infl ammation and oxidative stress,thus playing a key role in maintaining endothelial cell function.Unsurprisingly,low irisin levels cause endothelial dysfunction and increase the incidence of atherosclerosis.We aimed to summarize the studies on this issue since we have not found any review in the literature on the role of serum irisin levels in the process of atherosclerosis and other cardiovascular events in cardiovascular diseases.