Molecular communication is a novel nanoscale communication method. It can use ions, biochemical molecules or other information carriers to transmit information. However, due to molecules are easily accumulated in the channel to produce strong internal symbol interference, the information transmission in the channel is vulnerable to a low reliability. Therefore, reliability has become an important research issue in the field of molecular communication. At present, the existing reliability model of molecular communication does not take into account the drift velocity of the medium. Nevertheless, in some scenarios, it is often necessary to consider the effect of the drift velocity of the medium on the reliability of molecular communication. In this paper, we introduce the drift velocity of the medium and propose a reliability model of molecular communication based on drift diffusion (MCD2) in different topologies. Furthermore, in the case of transmission failure, a retransmission mechanism is used to ensure reliable transmission of information. Finally, we also compare the reliability performance of molecular communication between reliability model of MCD2 and reliability model of molecular communication based on free diffusion. The simulation results indicate that the proposed reliability model is superior to the existing reliability model of molecular communication based on free diffusion in analyzing the reliability of MCD2.