Epigenetic basis of Alzheimer disease

• 作者: Angeles C Tecalco-Cruz Jesus Zepeda-Cervantes JosuéO Ramírez-Jarquín María E Alvarez-Sánchez
• 来源期刊: 世界生物化学杂志:英文版(电子版)
• 学科: 医学
• 关键词: EPIGENETICS AGING Neurodegenerative diseases Alzheimer disease
• 年，卷（期）: 2020,（2）
• 页码范围: 62-75
• 页数: 14页
• 分类号: R74

摘要

Alzheimer disease(AD)is the primary form of dementia that occurs spontaneously in older adults.Interestingly,the epigenetic profile of the cells forming the central nervous system changes during aging and may contribute to the progression of some neurodegenerative diseases such as AD.In this review,we present general insights into relevant epigenetic mechanisms and their relationship with aging and AD.The data suggest that some epigenetic changes during aging could be utilized as biomarkers and target molecules for the prevention and control of AD.