Research progress on the role of cancer-associated fibroblasts in tumorigenesis and development

• 作者: Xiao-Hui Liu Xiong-Zhi Wu
• 来源期刊: 肿瘤微环境研究
• 学科: 医学
• 关键词: Cancer-associated FIBROBLASTS TUMOR MICROENVIRONMENT TUMOR ANGIOGENESIS INVASION Metastasis
• 年，卷（期）: 2020,（1）
• 页码范围: 29-33
• 页数: 5页
• 分类号: R73

摘要

Tumor microenvironment plays a very important role in the growth,invasion and metastasis of tumor cells.The tumor interstitial microenvironment is an important part of the tumor microenvironment,which includes two parts:the non-cellular and cellular components of the tumor interstitium,specifically including the extracellular matrix,blood vessels,and interstitial cells.Among them,activated interstitial fibroblasts,namely cancer-associated fibroblasts(CAFs),are the main components of tumor interstitial cells,which are most closely related to tumor interstitial fibrosis and tumor progress,and are expected to become a new target for cancer treatment.