To Explore the Potential Mechanism of Yiqing Capsule in the Treatment of COVID-19 Based on Network Pharmacology

• 作者: Jingyi Zhao Junhui Hu Song Jiang Xinhong Zhao Ying Wang Yinhui Yao
• 来源期刊: 中医(英文)
• 学科: 工学
• 关键词: Yiqing Capsule Network Pharmacology COVID-19
• 年，卷（期）: zyyw,（2）
• 页码范围: 96-104
• 页数: 9页
• 分类号: TP3

摘要

<b><span style="font-family:Verdana;">Objective: </span></b><span style="font-family:""><span style="font-family:Verdana;">To select the ingredients and targets of Yiqing capsule in treating COVID-19 based on network pharmacology, then to explore the potential mechanism of Yiqing capsule in treating COVID-19. </span><b><span style="font-family:Verdana;">Methods:</span></b> </span><span style="font-family:Verdana;">We </span><span style="font-family:Verdana;">screened the ingredients and targets of Yiqing capsule on Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and target genes for COVID-19 in GeneCards database</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> constructed drug-ingredient-target</span><span style="font-family:Verdana;"> network through software Cytoscape 3.7.2</span><span style="font-family:Verdana;">,</span><span style="font-family:""> </span><span style="font-family:Verdana;">and </span><span style="font-family:Verdana;">constructed protein protein interaction network (PPI) network through STRING database. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of key gene targets of Yiqing capsule </span><span style="font-family:Verdana;">are used to</span><span style="font-family:""><span style="font-family:Verdana;"> treat COVID-19 through software R5.3.2. </span><b><span style="font-family:Verdana;">Results</span></b></span><b><span style="font-family:Verdana;">: </span></b><span style="font-family:""><span style="font-family:Verdana;">We got 42 ingredients, 42 potential therapeutic targets, 1643 GO items and 970 pathways in our study. The main pathway including IL-17 signaling pathway, Chagas disease (American trypanosomiasis), Influenza A, and TNF signaling pathway. </span><b><span style="font-family:Verdana;">Conclusion</span></b></span><b><span style="font-family:Verdana;">: </span></b><span style="font-family:Verdana;">Yiqing capsule plays a role in treating COVID-19