Hydrocortisone, ascorbic acid and thiamine for sepsis: Is the jury out?

• 作者: Joseph Varon Paul Ellis Marik Salim R Surani
• 来源期刊: 世界糖尿病杂志:英文版(电子版)
• 学科: 医学
• 关键词: Diabetes VITAMIN C Ascorbic acid SEPSIS THIAMINE SEPTIC shock Global BURDEN of disease
• 年，卷（期）: 2020,（4）
• 页码范围: 90-94
• 页数: 5页
• 分类号: R73

摘要

Sepsis and septic shock remain a major cause of morbidity and mortality among patients admitted in the intensive care unit.Diabetes is a major risk factor for the development of sepsis.The global mortality of sepsis remains high,despite significant interventions and guidelines.It has been known for decades that patients with sepsis have reduced levels of antioxidants,most notably vitamin C.Furthermore,experimental data has demonstrated multiple beneficial effects of vitamin C in sepsis.In addition,corticosteroids and thiamine may have synergistic biological effects together with vitamin C.Preliminary data suggests that therapy with hydrocortisone,ascorbic acid and thiamine improves the outcome of patients with sepsis with the potential to save millions of lives.However,this intervention has met with much resistance and has not been widely adopted.Ultimately,we await the final jury verdict on this simple,safe and cheap intervention.