Association of Race and Change in Ankle-Brachial Index: The Atherosclerosis Risk in Communities (ARIC) Cohort

• 作者: Caroline Nievergelt Donna Kritz-Silverstein Ericha Franey Erin Richard John Alcaraz Richard Shaffer Vibha Bhatnagar
• 来源期刊: 老年问题研究(英文)
• 学科: 数学
• 关键词: ankle-brachial index ARIC PARAOXONASE PAD peripheral artery disease SNP single nucleotide polymorphism
• 年，卷（期）: 2020,（5）
• 页码范围: 77-93
• 页数: 17页
• 分类号: O17

摘要

<strong>Objective</strong>: <span><span><span style="font-family:verdana;">This study evaluates the association of self-reported race with</span><span style="font-family:'Minion Pro Capt','serif';"><span style="font-family:Verdana;"> change in ankle-brachial index (ABI) over time and modification of this association by paraoxonase gene (</span><i><span style="font-family:Verdana;">PON</span></i><span style="font-family:Verdana;">1,</span><i><span style="font-family:Verdana;"> PON</span></i><span style="font-family:Verdana;">2</span><i><span style="font-family:Verdana;"> and PON</span></i><span style="font-family:Verdana;">3) single nucleotide polymorphisms (SNPs). </span></span><b><span style="font-family:verdana;">Methods: </span></b></span></span><span style="font-family:verdana;"><span style="font-family:verdana;"><span style="font-family:verdana;"><span style="font-family:verdana;">This longitudinal study included 11,992 (N</span></span></span></span><span><span><span><span style="font-family:'Minion Pro Capt','serif';"> </span><span style="font-family:verdana;">=</span><span style="font-family:'Minion Pro Capt','serif';"> </span><span style="font-family:verdana;">2952 Black,</span><span style="font-family:'Minion Pro Capt','serif';"> </span><span style="font-family:verdana;">N</span><span style="font-family:'Minion Pro Capt','serif';"> </span><span style="font-family:verdana;">=</span><span style="font-family:'Minion Pro Capt','serif';"> </span><span style="font-family:'Minion Pro Capt','serif';"><span style="font-family:Verdana;">9040 White) participants from the Atherosclerosis Risk in Com</span><span style="font-family:verdana;">munities (ARIC) cohort with PON genotyping. Mixed-effects models ex</span><span style="font-family:Verdana;">amined whether race was associated with change in ABI over time after adjustment for known peripheral artery disease (PAD) risk factors.</span></span></span></span></span><span><span><span><span style="font-family:'Minion Pro Capt','serif';"> </span><b><span style="font-fam