Amino acid transporters: Emerging roles in drug delivery for tumor-targeting therapy

• 作者: Chengguang Sui Ling Zhang Qiuhua Luo Wenhan Yang
• 来源期刊: 亚洲药物制剂科学(英文)
• 学科: 化学
• 关键词: AMINO acid TRANSPORTER TUMOR-TARGETING Drug delivery PRODRUG NANOCARRIERS
• 年，卷（期）: 2020,（2）
• 页码范围: 192-206
• 页数: 15页
• 分类号: O62

摘要

Amino acid transporters,which play a vital role in transporting amino acids for the biosynthesis of mammalian cells,are highly expressed in types of tumors.Increasing studies have shown the feasibility of amino acid transporters as a component of tumortargeting therapy.In this review,we focus on tumor-related amino acid transporters and their potential use in tumor-targeting therapy.Firstly,the expression characteristics of amino acid transporters in cancer and their relationship with tumor growth are reviewed.Secondly,the recognition requirements are discussed,focusing on the“acidbase”properties,conformational isomerism and structural analogues.Finally,recent developments in amino acid transporter-targeting drug delivery strategies are highlighted,including prodrugs and nanocarriers,with special attention to the latest findings of molecular mechanisms and targeting efficiency of transporter-mediated endocytosis.We aim to offer related clues that might lead to valuable tumor-targeting strategies by the utilization of amino acid transporters.