The effect of tranexamic acid in patients with TBI: a systematic review and meta-analysis of randomized controlled trials

• 作者: Du Chao-nan Liu Bo-xue Ma Qing-fang Yang Ming-fei
• 来源期刊: 中华神经外科杂志（英文）
• 关键词: Traumatic brain injury Tranexamic acid Mortality Disability
• 年，卷（期）: 2020,（3）
• 所属期刊栏目: Review
• 页码范围: 171-177
• 页数: 7页
• 语种: 中文
• DOI: 10.1186/s41016-020-00196-z

摘要

To conduct a systematic review and meta-analysis and evaluate the effect of tranexamic acid in patients with traumatic brain injury. PubMed, EMBASE, and CENTRAL (Cochrane Central Register of Controlled Trials) were searched to identify randomized controlled trials and evaluate the effect of tranexamic acid in traumatic brain injury patients. The primary outcome was mortality. Two reviewers extracted the data independently. The random effect meta-analysis was used to estimate the aggregate effect size of 95% confidence intervals. Six randomized controlled trials investigating tranexamic acid versus placebo and 30073 patients were included. Compared with placebo, tranexamic acid decreased the mortality (RR = 0.92; 95% CI, 0.87-0.96; p < 0.001) and growth of hemorrhagic mass (RR = 0.78; 95% CI, 0.61-0.99; p = 0.04). However, tranexamic acid could not decrease disability or independent, neurosurgery, vascular embolism, and stroke. Current evidence suggested that compared with placebo, tranexamic acid could reduce mortality and growth of hemorrhagic mass. This finding indicated that patients with traumatic brain injury should be treated with tranexamic acid.