Evaluation the Possibility of Using of miRNA-21 as a Prognostic and Predictive Factor in Colorectal Cancer (South Egypt Experience)

• 作者: Abeer Ibrahim Ashraf Zedain Dina Ismail Abd El Razik Hosny Badrawy Mayada Fawzy Sanaa Saber
• 来源期刊: 癌症治疗(英文)
• 学科: 医学
• 关键词: CRC MIRNA-21 PROGNOSTIC PREDICTIVE
• 年，卷（期）: azzlyw,（2）
• 页码范围: 88-97
• 页数: 10页
• 分类号: R73

摘要

Background: Micro RNA 21?(miRNA-21) is overexpressed in numerous solid types of tumors, indicating that its biology is relevant to numerous types of cancer. However,?in Colorectal Cancer (CRC)?there is a lot of studies?confirmed its use as diagnostic marker, other studies suggested it could be used as a predictive marker for 5 Fu sensitivity so this study was conducted to verified the significance of using miRNA-21 as a prognostic and predictive factor in CRC. Patients and Methods: It is a prospective study that included 45 patients with stage I-IV CRC who attended at South Egypt Cancer Institute from April 2017 to October 2018.?miRNA-21 was measured by (q PCR) from peripheral blood.?Response to 5-FU containing regimens was assessed using RECIST?criteria and its levels of expression were correlated to the clincopathological data,?response and survival of the patients.?Results:?High expression of the miRNA21 was significantly associated with advanced stage of CRC p ?0.001,?Lymph Node (LN)?invasion p ?0.001,distant metastasis p??0.01 lymphovascular (LVI) invasion p ?0.01 and pre-treatment level of Carcino?Embryonic Antigen (CEA) p ?0.031. Also we found that high expression level significantly badly affected the response to 5-Fu containing regimen p ?0.001, DFS p ?0.01.?Conclusion:?miRNA-21 could be used as non-invasive prognostic and predictive marker in CRC.