Associations between Vaspin Levels and Coronary Artery Disease

• 作者: Hakan Tibilli Lutfu Askin Okan Tanriverdi Serdar Turkmen
• 来源期刊: Cardiovascular Innovations and Applications
• 学科: 医学
• 关键词: ADIPOKINE ATHEROSCLEROSIS infl ammation CORONARY ARTERY disease VASPIN
• 年，卷（期）: 2020,（1）
• 页码范围: 211-216
• 页数: 6页
• 分类号: R58

摘要

The relationship between serum vaspin levels and metabolic or coronary artery disease is currently of interest for researchers.Although adipokine concentrations have been shown to be increased signifi cantly in atherosclerotic lesions,the role adipokines in the atherosclerotic process remains to be elucidated.Vaspin is a new biological marker associated with obesity and impaired insulin sensitivity.Plasma vaspin concentration has been shown to correlate with the severity of coronary artery disease.Vascular infl ammation triggered by vaspin inhibits atherogenesis by suppressing macrophage foam cell formation and vascular smooth muscle cell migration and proliferation.Vaspin also contributes to plaque stabilization by increasing collagen content and reducing the intraplaque macrophage to vascular smooth muscle cell ratio.The therapeutic goal concerning vaspin is to fi ght atherosclerosis and related diseases,as well as to maintain vascular health.