Patient Characteristics Associated with Non-Adherence to Tuberculosis Treatment: A Systematic Review

• 作者: A. O. A. Ali Martin H. Prins
• 来源期刊: 结核病研究(英文)
• 学科: 医学
• 关键词: TUBERCULOSIS NON-ADHERENCE ADHERENCE Defaulter COMPLIANCE
• 年，卷（期）: 2020,（2）
• 页码范围: 73-92
• 页数: 20页
• 分类号: R52

摘要

<b>Background:</b><b> </b>A high level of adherence to treatment is essential for cure and prevention of tuberculosis (TB) treatment resistance. <b>Methods:</b><b> </b>A Systematic review of 53 studies addressing the patient characteristics associated with TB medication non-adherence was performed. The publications were identified by searching the PubMed, World Health Organization (WHO), and Centers for Disease Control and Prevention (CDC) database, EmBase, Scopus database Arts, Humanities, Social Science database and Google scholar. Only English language publications were eligible. Potentially eligible studies were retrieved and the full articles were assessed. The potentially eligible studies were included if they concerned patients treated for tuberculosis, reported non adherence and reported on potential risk factors associated with non-adherence. <b>Results:</b> Factors that were most frequently consistently and statistically significantly related to non-adherence to tuberculosis treatment were: family income, patient movement and changing address or giving wrong address, tuberculosis relapse or multidrug-resistant TB (MDRTB), during intensive phase of treatment, history of default, treatment regimen (long course), response to treatment, homeless, stigma, seeking traditional healers, staff receptiveness, lack of directly observed therapy short course (DOTS), poor knowledge or lack of health education, side effects of drugs, feeling better, alcohol intake and lack of family and social support. <b>Conclusions:</b> Non-adherence to tuberculosis treatment was influenced by several factors.