Circulating platelet miRNAs for coronary artery disease and acute myocardial infarction elderly patients

• 作者: Jing He Shi-Jun Li
• 来源期刊: 衰老研究
• 学科: 医学
• 关键词: Acute myocardial infarction Coronary artery disease PLATELET MIRNA
• 年，卷（期）: 2020,（2）
• 页码范围: 45-51
• 页数: 7页
• 分类号: R54

摘要

Background:Platelet activation is considered as the early stage of thrombus,which is important to thrombogenesis in acute myocardial infarction.Platelet miRNAs could be regarded as biomarkers of platelet activation.Here,the expression of platelet miRNA-200b and miRNA-223 were detected to predict platelet activation in acute myocardial infarction.Methods:Twenty elderly acute myocardial infarction patients(group A),20 elderly coronary artery disease patients(group B),and 20 healthy elder people(group C)were included in our research.The platelet miR-200b and miR223 were determined using fluorogenic quantitative polymerase chain reaction.Results:Platelet miR-200b and miR-223 were differentially expressed among the acute myocardial infarction patients,coronary artery disease patients and control groups.Acute myocardial infarction patients had the highest expression of platelet miR-200b and miR-223,while coronary artery disease patients had the lowest level(P<0.05).Conclusions:For the elderly,platelet miRNA regarded as the biomarker of platelet activation was an easy method to discover acute cardiovascular events.