The emerging role of tubulin posttranslational modifications in cilia and ciliopathies

• 作者: Jinghua Hu Kai He Kun Ling
• 来源期刊: 生物物理学报:英文版
• 学科: 医学
• 关键词: Tubulin posttranslational modifications(PTMs) CILIA Ciliopathies ACETYLATION Glutamylation Glycylation
• 年，卷（期）: swwlxbywb_2020,（4）
• 页码范围: 89-104
• 页数: 16页
• 分类号: R32

摘要

Tubulin posttranslational modifications(PTMs)add*tubulin code*to generate functional diversities of microtubules.Several types of tubulin PTMs accumulate on axonemes and basal bodies of cilia,including acetylation,glutamylation,glycylation and detyrosination.Among them,glutamylation,glycylation and detyrosination are mostly enriched in the B-tubules,whereas acetylation occurs on both Aand B-tubule of the microtubule doublets in a similar level.Recent studies indicate that tubulin PTMs are critical for the fine tuning of assembly/disassembly,maintenance,motility,and signaling of cilia.Dysregulated tubulin PTMs are strongly implicated in human disorders including ciliopathies and neuron degeneration.Here,we review the current understanding how tubulin PTMs regulate cilia formation and function,and their relevance to human health.