Metabolomics and its application in the evaluation of toxicity of traditional Chinese medicine

• 作者: Ming Huang Ning Fan Peng Lu Xian-Bin Kong Xiao-Xin Dou Yi-Hua Fan Yu-Ying Yang Zhi-Chao Wang
• 来源期刊: 亚洲毒理学研究
• 学科: 工学
• 关键词: Metabolomics TOXICITY TRADITIONAL CHINESE MEDICINE Compatibility
• 年，卷（期）: 2020,（2）
• 页码范围: 61-70
• 页数: 10页
• 分类号: TP3

摘要

Metabolomics is a newly developed discipline following genomics,transcriptomics,and proteomics.It is based on the theory of systems biology,supported by modern spectroscopy analysis technology and is analyzed by the external stimulation of organisms.By analyzing the overall changes of metabolites with low molecular weight in organism after being stimulated by the outside world,we can understand the physiological and pathological state of organism,and finally clarify the essence of biological changes of organism.In recent years,metabolomics has developed rapidly.It has been widely used in early toxicity screening of lead compounds,preclinical toxicity of drugs and toxicity evaluation of clinical drugs.The in-depth interpretation of metabolomics results is also developing.This article reviewed the progress of metabolomics technology and its application in the study of toxicity evaluation of traditional Chinese medicine.