Traditional Chinese medicine treatment of immune-related pneumonia caused by PD-1/PD-L1 inhibitors

• 作者: Bing Dai Liang Lei Xun Sun
• 来源期刊: TMR临床研究
• 学科: 医学
• 关键词: PD-1/PD-L1 inhibitor Immune-related pneumonia TCM syndrome differentiation Prevention and treatment
• 年，卷（期）: 2020,（2）
• 页码范围: 63-69
• 页数: 7页
• 分类号: R73

摘要

With the wide application of immunotherapy drug PD-1/PD-L1 inhibitor in China and the continuous clinical research,a major problem that we have to face is the immune-related pneumonia caused by PD-1/PD-L1.At present,western medicine mainly treated it by hormone therapy,which may cause side effects,such as obesity,osteoporosis and osteonecrosis for hormone therapy by long-term,and increase the patients'pain.Under the guidance of the theory of syndrome differentiation,traditional Chinese medicine(TCM)advocates the methods of expelling wind and clearing away cold,resolving phlegm and relieving asthma,relieving heat from lung,and invigorating the spleen and tonifying the kidney,etc.Exact differentiation of symptoms and rational usage of drugs can play an important role in the early prevention and treatment of immune-related pneumonia,reflecting the important role of TCM in the prevention and treatment of side effects of new drugs.In order to provide an effective clinical reference for clinicians in the practice of using PD-1/PD-L1,this paper systematically reviewed the use of TCM in the treatment of immune-related pneumonia induced by PD-1/PD-L1 inhibitors.