Research progress on the influence of opioids on fetal neurodevelopment during pregnancy

• 作者: Ju Chen Shu-Ting Wei Xia-Lei Li Yi-Bo Wu Yue-Han Guo
• 来源期刊: TMR生命研究
• 学科: 医学
• 关键词: PREGNANT WOMEN Unreasonable use of OPIOIDS FETAL NEURODEVELOPMENT Improvement measures
• 年，卷（期）: 2020,（2）
• 页码范围: 68-77
• 页数: 10页
• 分类号: R71

摘要

Women usually suffer from chronic pain due to pregnancy or have an increased level of chronic pain.In view of the definite curative effect of opioids on chronic pain and opioid use disorders,opioids have attracted much attention in the treatment of bone,joint,neuropathic and other chronic pain and opioid use disorders in pregnant women.Considering that the unreasonable use of opioids by pregnant women will lead to risks such as drug accumulation and increased neural sensitivity in the fetus,the correct and reasonable use of opioids is the key to the treatment.In recent years,it has been found that opioids can cross the blood fetal barrier into the fetal circulation,and damage fetal nerve development to varying degrees.However,the studies on the typical diseases such as neonatal neural tube defects and neonatal abstinence syndrome are not comprehensive.Therefore,this article has clarified the unreasonable use of opioids during pregnancy and its effect on fetal nerve development,and put forward relevant measures in order to provide reference for clinicians/pharmacists in obstetrics and gynecology.