Analysis of the action mechanism of Si-Jun-Zi decoction in cataract by network pharmacology

• 作者: Li-Jin You Yan-Hong Hu Zhao-Da Ye Zi-Yang Chen
• 来源期刊: TMR医学数据挖掘
• 学科: 工学
• 关键词: Network pharmacology CATARACT Si-Jun-Zi decoction Action target Genetic ontoloy
• 年，卷（期）: tmrxysjwj_2020,（4）
• 页码范围: 177-184
• 页数: 8页
• 分类号: TP3

摘要

Background:To explore the action mechanism of the classic ancient prescription Si-Jun-Zi decoction in slowing down cataract process by network pharmacology.Methods:In Traditional Chinese Medicines for Systems Pharmacology Database and Analysis Platform Database,screening the chemical components and functional targets of the classic ancient prescription Si-Jun-Zi decoction,and the targets of cataract disease were obtainded through GeneCards and the Online Mendelian Inheritance in Man Database.In the STRING database,the protein-protein interaction network was built.And network visualization were created in Cytoscape.The genetic ontology and Kyoto Gene and Genome Encyclopedia pathways of key proteins were enriched via the DAVID data platform.Results:Ninety-six active components and 33 key targets were obtained in this work.The protein-protein interaction network consisted of 33 proteins.There were 33 genetic ontology entries and 72 Kyoto Gene and Genome Encyclopedia pathway enrichment analysis.Conclusion:This work provided a new means to understand the pathogenesis of cataract and revealed the action mechanisms of the classic ancient prescription Si-Jun-Zi decoction.