Histopathology and Morphometric Analysis of the Internal Mammary Artery to Study the Incidence of Atherosclerosis and Its Associated Risk Factors

• 作者: H. V. Jayanth Kumar Kumsi Sreedhar S. R. Kalpana Shilpa Suresh Sumithra Selvam
• 来源期刊: 心血管外科国际期刊(英文)
• 学科: 医学
• 关键词: ATHEROSCLEROSIS CALCIFICATION Coronary Artery Bypass Graft Intimal Hyperplasia
• 年，卷（期）: 2020,（6）
• 页码范围: 67-74
• 页数: 8页
• 分类号: R54

摘要

<strong><span style="font-family:Verdana;">Background:</span></strong> <span style="font-family:;" "=""><span style="font-family:Verdana;">The left internal mammary artery (IMA) is widely used as a conduit for coronary revascularization. The incidence of atherosclerosis is known to be lower in the IMA than in the coronary artery. The aim of this study was to evaluate the reliability of the use of the distal section of the IMA as an anastomotic site for bypass grafting and morphometric studies of IMA in patients with proven coronary artery disease and their associated risk factors. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">Patients who underwent Coronary Artery Bypass Graft (CABG) from June 2010 to November 2012 were chosen in this retrospective study and the discarded distal segments of the internal mammary artery were analyzed. The potential risk factors for atherosclerosis considered were age, sex, diabetes mellitus, history of cigarette smoking, hypertension and hypercholesterolemia. The samples were analyzed for the degree of intimal thickening and atherosclerosis by calculating the percentage of Luminal Narrowing, Intimal Thickness Index (ITI) and Intima-to-Media Ratio (IMR). </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">There were seven cases of intimal hyperplasia and two cases of focal medial and intimal hyperplasia with fatty streak and no cases of atherosclerosis and medial calcification. ITI was higher in males when compared to females. There was a strong relationship between IMR and smokers when compared to nonsmokers. </span><b><span style="font-family:Verdana;">Conclusion: </span></b><span style="font-family:Verdana;">In our study, when ITI was used as the dependent variable, diabetes was the most important factor. When IMR was used, the strongest predictor was hypercholesterolemia. There was a strong relationship between IMR and smokers when compared to nonsmokers.</span></span>