Effects of 5-hydroxytryptamine Receptor on the Reaction of the Lower Esophageal Sphincter Under the Electrical Field Stimulation

• 作者: Ben Li Hefei Li Qiang Guo Tao Jiang Wei Li Xinbo Liu Yong Feng Zhenqing Sun
• 来源期刊: 临床护理研究
• 学科: 医学
• 关键词: 5-hydroxytryptamine(5HT)receptors LOWER ESOPHAGEAL Sphincter(LES) In-vitro MUSCLE tension
• 年，卷（期）: 2020,（2）
• 页码范围: 1-8
• 页数: 8页
• 分类号: R73

摘要

In the first and second parts of this study,5-hydroxytryptamine(5HT)receptors,including 5-HT3 and 5-HT4 with the highest expression level,were found in clasp and sling fibres of the lower esophageal sphincter(LES).Specific 5-HT3 and 5-HT4 receptor agonists can induce the contraction effect of clasp and sling fibres of the LES while specific 5-HT7 receptor agonists showed no effects.In the study of this part,the in-vitro muscle tension measurement technology and EFS methods were used to detect the effect of the selective 5-HT receptor antagonist on the clasp and sling fibres of the in-vitro LES under the electrical field stimulation(EFS),and further to ensure the effect of 5-HT receptor in the LES neuroregulatory pathway,and deeply explore the effect of 5-HT receptor in the systolic and diastolic function regulation of the LES.