A preliminary study on the anti-inflammatory and analgesic effects of two extracts of pine pollen on anoxia and fatigue resistance

• 作者: Han-Jun Ma Hui-Man Yang Shi-Bo Zhao Suo-Yi Huang Xue-Ying Yu Yi-Jie Wang Yu-Xin Wei Yu-Zhu Zeng Zhong-Gang Wu
• 来源期刊: 衰老研究
• 学科: 医学
• 关键词: Pine pollen Alcohol extract Water extract Anti-inflammatory effect Analgesic effect ANTIHYPOXIA Fatigue resistance
• 年，卷（期）: 2020,（2）
• 页码范围: 59-66
• 页数: 8页
• 分类号: R28

摘要

Background:To study the anti-inflammatory,analgesic,fatigue resistant and antihypoxia effects of ethanol extract and water extract of pine pollen.Methods:Two different extracts of pine pollen were prepared into there different concentrations,that is 1.5 mg·mL^-1,4.5 mg·mL^-1 and 7.5 mg·mL^-1 respectively.The extract were studied by xylene-induced ear swelling,acetic acid distortion test and hot plate test.The antihypoxia and antifatigue effects were explored by weight-bearing swimming experiment,routine pressure hypoxia tolerance experiment and liver weight coefficient comparison.Results:Through the study of the four pharmacological effects of ethanol extract and water extract,we found that the anti-inflammatory,analgesic,antithyposia and antifatigue effects of ethanol extract were better than that of water extract.Moreover,the experimental effects significantly improved with the increase of the concentration,and the effect of alcohol increased dose group was accurate(P<0.05).Conclusion:Pine pollen has excellent effects of anti-inflammatory,analgesic,antihypoxia and anti-fatigue.Besides,with the increase of drug concentration,effects tend to be more obvious with positive correlation.