Bitter components related to alleviating intestinal obstruction in traditional Mongolian medicine

• 作者: Gen-Na Ba Hong-Zhen Yu Li-Sha A Ming-Hai Fu Peng-Fei Han Sung-Bo Cho Xiao-Ping Ji
• 来源期刊: TMR理论与假说
• 学科: 医学
• 关键词: Intestinal obstruction Mongolian medicine Bitter taste receptors Signal transduction pathway
• 年，卷（期）: 2020,（2）
• 页码范围: 337-347
• 页数: 11页
• 分类号: R56

摘要

Intestinal obstruction is a blockage that keeps digesta from passing through upper or lower intestine.Traditional Mongolian medicine(TMM)has been proven to be efficacious in the clinical treatment of intestinal obstruction.However,the mechanism of its treatment has not been studied.The bitter taste receptors(T2Rs)are highly expressed in the extra-oral digestive system,such as gastrointestinal tract,which can regulate gastrointestinal peristalsis and contraction of gastrointestinal smooth muscle.In the respiratory system,T2Rs can relax the airway smooth muscle and effectively alleviate asthma symptoms.In this review,the theory and clinical applications of bitter herbs in TMM were discussed and the functional expression of T2Rs and bitter taste signal transduction pathway were analyzed to investigate whether bitter Mongolian medicine may play an effective role in promoting gastrointestinal peristalsis.Therefore,the scientific connotation of the theory of bitter medicinal property of TMM was interpreted by combining T2Rs research and application of modern technology.This new research approach may enrich and improve the basic theory and accelerate the modernization of TMM.