The Pattern of Haematological Changes in the Baseline Blood Cell Counts and the CD4⁺T Lymphocyte Levels among Antiretroviral Therapy Naïve Adult HIV Positive Patients in a Nigerian Hospital

• 作者: Abiola Omosalewa Alao Adewunmi James Aremu Oladunni Olajumoke Adegbite Olawunmi Femi Olaosebikan Taiwo Modupe Balogun
• 来源期刊: 血液病期刊(英文)
• 学科: 数学
• 关键词: HAEMATOLOGY COMPLICATIONS HIV Infection NIGERIA
• 年，卷（期）: 2020,（3）
• 页码范围: 77-88
• 页数: 12页
• 分类号: O17

摘要

<b><span style="font-family:Verdana;">Background: </span></b><span style="font-family:Verdana;">Haematological abnormalities are strong independent predictors of morbidity and mortality in HIV infection.</span><span style="font-family:;" "=""> </span><b><span style="font-family:Verdana;">Objectives of the Study:</span></b><span style="font-family:Verdana;"> This study was carried out to assess the pattern of the changes in the baseline peripheral blood cell counts among adult HIV positive patients. To also determine the </span><span style="font-family:;" "=""><span style="font-family:Verdana;">CD4</span>^{<span style="font-family:Verdana;">+</span>}</span><span style="font-family:Verdana;"> T</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cell levels and its correlation with the changes in the baseline cell counts of the patients using HIV negative blood donors as controls.</span><span style="font-family:;" "=""> </span><b><span style="font-family:Verdana;">Methods</span></b><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"> This was a case controlled prospective study. The subjects were antiretroviral therapy naive adult HIV positive patients and HIV negative blood donor controls. Five milliliters (5</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">mls) of venous blood was collected from the cubitus of every consecutive consenting subject. Blood sample was analysed for baseline complete blood cell counts and the </span><span style="font-family:;" "=""><span style="font-family:Verdana;">CD4</span>^{<span style="font-family:Verdana;">+</span>}</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">T lymphocyte levels using Sysmex and Cyflow R Counter autoanalysers respectively. Obtained data was analysed with the statistical package for the social scientist (SPSS version 20.0). The Erythrocyte sedimentation rate of subjects was measured b