Pathogenic microbial biological epidemics can cause negative emotions such as fear,anxiety,loneliness and depression,as well as somatization symptoms such as insomnia,headache,chest tightness and degenerative behavior.As a secondary disaster of major epidemic situation,this kind of adverse psychological stress needs to be adjusted quickly.The author reviews the rapid psychological regulation methods of novel coronavirus pneumonia(coronavirus disease 2019,Covid-19),aiming to provide a useful enlightenment for the prevention of psychological stress in microorganism epidemic situation.