CDC20,TOP2A and NEK2 Expression in Esophageal Squamous Cell Carcinoma and Its Clinical Significance

• 作者: Longying He Qian Zhang Xinglong Zhang Yanjiao Liu
• 来源期刊: 肿瘤学研究(英文)
• 学科: 医学
• 关键词: Esophageal squamous cell carcinoma CDC20 TOP2A NEK2 Clinical significance
• 年，卷（期）: 2020,（2）
• 页码范围: 41-44
• 页数: 4页
• 分类号: R73

摘要

Objective:to study the expression and clinical significance CDC20,TOP2A,NEK2 esophageal squamous cell carcinoma.Methods:To select 70 patients with esophageal squamous cell carcinoma,Between August 2018-August 2020,All intraoperative pathological specimens,A group-35 cases),Cancer tissue,B group,adjacent tissues),two groups of CDC20,TOP2A,NEK 2 expression were detected and analyzed by immunohistochemistry and semi-quantitative reverse transcription polymerase chain reaction-RT-PcR)assay.Results:the values of CDC20,TOP2A,NEK2 expression level in A group were significantly higher than those in B group-P<0.05).The expression level CDC20,TOP2A,NEK2 esophageal squamous cell carcinoma was positively correlated with TNM stage and lymphatic metastasis,and negatively correlated with tumor differentiation.Conclusion:CDC20,TOP2A,NEK2 high expression level directly affects the metastasis,recurrence and prognosis of esophageal squamous cell carcinoma.The combination of three indexes can accurately evaluate the pathological status of patients with esophageal squamous cell carcinoma and help to judge the prognosis of patients accurately.