Cancer Uses the Common Morphogenesis Source of the Host

• 作者: Aleksey N. Shoutko
• 来源期刊: 生物物理学期刊(英文)
• 学科: 医学
• 关键词: Rate of Death Body Weight CANCER Non-Cancer Diseases Age Limphocytopoiesis Moprphogenesis Survival POPULATIONS
• 年，卷（期）: 2020,（4）
• 页码范围: 175-190
• 页数: 16页
• 分类号: R73

摘要

Trophic properties of hematopoietic stem cells can influence the malignant growth alternatively to immune control. The annual growth of the body mass by age in adult populations of welfare countries used as the most common criterion of metabolic and proliferative tissue activity, and these data compared with death’ rate for malignant and somatic diseases in different age-groups of the same countries. The rate of physiologic involution of different cell populations in the lymphoid lineage by age also involved in correlations between the above parameters. A decrease in death rate for cancer and increase it’s for non-malignant diseases found in 60+ populations, which have the lowest physiological temp of renewal of lymphocytes number and mass of the body. The lack of both the thymus gland volume and proliferative activity of naive lymphocytes reduces physiological body mass renewal as well as the cancer death rate but enhances somatic death rate, opposing to anticancer immunity at large. A protumor character of the lymphopoietic system’s relation with malignancy seems more realistic than defending one.