Examination of Urinary Chlorpyrifos Biomarker Concentrations and Heart Rate in a Sample of US Children and Adolescents

• 作者: Raymond Harbison
• 来源期刊: 职业病与环境医学(英文)
• 学科: 农学
• 关键词: CHLORPYRIFOS Organophosphates PESTICIDES Acetylcholinesterase Inhibitors TCPy Heart Rate Pulse CARDIOVASCULAR Exposure Urinary Metabolites Children YOUTH Adolescents
• 年，卷（期）: 2020,（4）
• 页码范围: 163-174
• 页数: 12页
• 分类号: S48

摘要

<strong>Objective:</strong> The purpose of the investigation is to determine if a relationship exists between heart rate and urinary biomarkers of chronic, subacute chlorpyrifos pesticide exposure in youth. <strong>Methods:</strong> Using 2001-2002 NHANES data, a sample of 1233 children ages 6 - 18 was grouped based on detection status of 3,5,6-trichloropyridinol (TCPy) in urine. Radial pulse and brachial pulse were recorded as measures of heart rate by physicians. <em>T</em>-tests and linear regression analyses were performed to test for associations between TCPy concentrations and heart rate. <strong>Results:</strong> None of the associations between TCPy levels and heart rate outcomes were found to be significant. Nonsignificant effects in the TCPy-detected groups included a slightly reduced heart rate in girls, as well as a slightly elevated heart rate in boys when compared to the undetected controls. Neither was there any significant observable difference in heart rate due to detection status in the sample overall. <strong>Conclusions:</strong> At this time, an effect on heart rate attributable to chronic, low-level chlorpyrifos exposure in youth cannot be determined. Children and adolescents detected did not demonstrate a substantial change in pulse measures when compared to controls. It is recommended that subsequent studies examine chlorpyrifos biomarkers as they may relate to other indicators of cardiovascular health.