Synergistic effects of Mg-substitution and particle size of chicken eggshells on hydrothermal synthesis of biphasic calcium phosphate nanocrystals

• 来源期刊: 材料科学技术（英文版）
• 年，卷（期）: 2020,（1）
• 页码范围: 27-36
• 页数: 10页
• 语种: 英文

摘要

Magnesium (Mg2+) ion plays important roles in biomineralization of bone,teeth and calcium carbonate skeletons.Herein,chicken eggshells mainly comprising of Mg-calcite nanocrystals (Mg/(Mg+Ca) (2).0 mol.％) were used to fabricate biphasic calcium phosphate (BCP),a mixture of hydmxyapatite (HA) and β-tricalcium phosphate (β-TCP) nanocrystals,through hydrothermal reactions at 200℃ for 24h.Our results indicated that β-TCP nanocrystals formed through the ion-exchange reactions of Mg-calcite,while HA nanocrystals were mainly produced by dissolution-reprecipitation reactions on the surfaces of eggshell samples in the hydrothermal system.Mg substitution in calcite resulted in formation of β-TCP nanocrystals instead of HA crystals through ion-exchange reactions.BCP samples with different compositions ((2)8.6-77.8 wt.％ β-TCP) were produced by controlling particle sizes of eggshells for hydrothermal reactions.The larger particles lead to the larger proportion of β-TCP in the BCP composition.Therefore,Mg substitution and particle size had synergetic effects on the hydrothermal synthesis of BCP using chicken eggshells through balance of ion-exchange and dissolution-reprecipitation reactions.Cell culture results showed that the BCP products were non-cytotoxic to MC3T3-E1 cells,which may be used for bone substitute materials in future.