Microarray analysis of genes involved in mice heart tissues of cardiac hypertrophy

• 作者: FU Zhen-yang LIN Ji-jin
• 来源期刊: 岭南心血管病杂志（英文版）
• 关键词: cardiac hypertrophy cell proliferation immune response core gene microarray analysis
• 年，卷（期）: 2020,（2）
• 页码范围: 138-146
• 页数: 9页
• 语种: 英文

摘要

Backrround Cardiac hypertrophy (CH) is a pathological state of heart which could lead to arrhythmias,cardiac failure,and sudden cardiac death.Pathology of cardiac hypertrophy has been acknowledged widely,but the detailed molecular mechanism has not been explored thoroughly.Our study was designed to identify differentially expressed genes(DEGs),and to explore the molecular mechanism and core genes that may be involved in the progression of cardiac hypertrophy.Methods Microarray data of cardiac hypertrophy (GSE76) was downloaded from the Gene Expression Omnibus (GEO) database.The DEGs were identified by R.Then Gene Ontology(GO),Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and protein-protein interaction (PPI) network analyses were performed by DAVID,STRING and Cytoscape.Results 1014 DEGs in GSE76 were identified,970 were downregulated genes and 44 were upregulated genes in cardiac hypertrophic tissues.The biological process (BP)analysis revealed that DEGs mainly included genes for inflammatory response,cell adhesion,and cell proliferation.The core genes were associated with cardiac remodeling and fibrosis,cell growth,inflammatory reaction,and cell adhesion.Conclusions This study indicated the potential significance of immune injury and cardiac fibrosis in the progression of cardiac hypertrophy.Meanwhile,the core genes may provide molecular targets for the disease diagnosis or drug treatment of cardiac hypertrophy in the future.