Clinical observation of 36 patients with chronic nephritis proteinuria treated with Zhuangshen Gujing decoction

• 作者: Li-Chang Liu Min-Jian Feng Qi Huang Wei-Hong Hong Xin Liu Xue-Fei Du Yu-Yan Jin
• 来源期刊: TMR临床研究
• 学科: 医学
• 关键词: Zhuangshen Gujing decoction Chronic nephritis PROTEINURIA Clinical observation
• 年，卷（期）: 2020,（3）
• 页码范围: 103-108
• 页数: 6页
• 分类号: R28

摘要

Objective:Our goal was to examine the impact of Zhuangshen Gujing decoction on proteinuria associated with chronic nephritis.Methods:72 patients with chronic nephritis proteinuria were divided randomly into two groups;one group was treated with Zhuangshen Gujing(n=36;treatment group)and the other group was treated with irbesartan(n=36;control group).After 6 months’treatment,urine protein and renal function were evaluated.Results:Proteinuria resolved completely in four patients in the treatment group;complete disease resolution was observed only among three individuals in the control group.Of the 32 cases remaining in the treatment group,15 had substantial responses to Zhuangshen Gujing decoction,9 had partial responses,and 8 had no response to treatment;the overall the response rate was 73.33%.Among the 33 cases remaining in the control group,12 had a substantial response to irbesartan,5 had a partial response,and 16 had no response to treatment;the overall response rate among the controls was 57.67%(P=0.031).We also observed statistically significant differences with respect to quantitative comparisons of urinary protein at 24 days after a single course of treatment(P=0.001).Conclusion:Zhuangshen Gujing decoction is effective in treating chronic nephritis proteinuria.