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摘要:
A tablet matrix system was developed for ibuprofen and the influence of the polymer blend and concentration on the release rate of the drug was evaluated.Tablets containing different concentrations of calcium silicate and PVP(polyvinyl pyrrolidone)were prepared using direct compression and the weight uniformity,crushing strength,friability,drug content uniformity,dissolution profile,and in vitro release kinetics were examined.Formulated tablets were found to be within the official acceptable limits of physical and chemical parameters except for the thickness test that was below the conformation of extended-release tablets.The crushing strength of the tablets was in the range of 2.5 to 5.6 kg/f,the weight variations of the tablets of all the formulation was less than±5%.The friability of all the formulations was in the range of 0.6%to 1.83%.Tablet thickness and diameter was in range of 3.18 mm to 4.48 mm and 12.53 mm to 12.64 mm respectively.Absolute drug contents of all the formulations were found to be in range of 83.50%to 98%.The release kinetic of F3 containing 20 mg of calcium silicate,40 mg of PVP as matrix formers showed the best linearity(r^2=0.6975)with%drug release of 96 showing that combination of the two polymers(20 mg calcium silicate and 40 mg PVP)for use as a matrix former is best for extended-release formulation of ibuprofen.
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篇名 Development of Extended-Release Formulation of Ibuprofen Using Blends of Calcium Silicate and Polyvinyl Pyrrolidone as Tablet Matrix
来源期刊 化学与化工:英文版 学科 化学
关键词 Calcium silicate IBUPROFEN ER(extended release) dissolution profile release properties
年,卷(期) 2020,(4) 所属期刊栏目
研究方向 页码范围 119-128
页数 10页 分类号 O63
字数 语种
DOI
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研究主题发展历程
节点文献
Calcium
silicate
IBUPROFEN
ER(extended
release)
dissolution
profile
release
properties
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
化学与化工:英文版
月刊
1934-7375
武汉洪山区卓刀泉北路金桥花园C座4楼
出版文献量(篇)
1069
总下载数(次)
2
总被引数(次)
0
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