Treatment of Helicobacter pylori infection in children:A systematic review

• 作者: Breno Bittencourt de Brito Camilo Santana Silva Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Filipe Antônio França da Silva Gifone Aguiar Rocha Hanna Santos Marques Jonathan Santos Apolonio Lorena Sousa de Carvalho Luana Kauany de SáSantos Márcio Vasconcelos Oliveira Maria Luísa Cordeiro Santos Mariana Miranda Sampaio Ronaldo Teixeira da Silva Júnior
• 来源期刊: 世界荟萃分析杂志
• 学科: 医学
• 关键词: Helicobacter pylori CHILDREN Pediatric treatment Standard triple therapy PROBIOTICS Sequential therapy Eradication therapies
• 年，卷（期）: 2020,（4）
• 页码范围: 292-308
• 页数: 17页
• 分类号: R57

摘要

BACKGROUND Helicobacter pylori(H.pylori)infection is predominantly acquired in childhood.When indicated,the most accepted treatment for H.pylori eradication in this age group is first-line triple therapy.However,the increasing resistance to clarithromycin and nitroimidazoles has been associated with treatment failure,and thus,alternative treatment regimens have been proposed.AIM To perform a systematic review of randomized controlled trials on treatment regimens for H.pylori infection in children.METHODS We surveyed relevant articles published in English from 2010 to April 2020 in the PubMed and MEDLINE databases.Keywords included“Helicobacter pylori“/”children or childhood“/”treatment or eradication.”The risk of bias was evaluated according to the Cochrane Handbook of Systematic Reviews for Interventions.RESULTS Among the 1144 records identified through the database,20 articles were selected.Four studies compared the eradication rates of H.pylori infection between standard triple therapies,changing only the main antibiotic used.Seven studies evaluated the effectiveness of standard triple therapy with the addition of probiotics.One study investigated the relationship between the effectiveness in the eradication rates of standard triple therapy and vitamin E levels.Six studies analyzed the eradication rates of sequential therapy.CONCLUSION The findings suggest that although standard triple therapy is the most recommended regimen for children by the current guidelines,other therapeutic schemes have shown promising results and may also be recommended for clinical practice in the future.